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Old October 5th, 2013, 05:59 PM   #41
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Three parent babies 'incompatible with human dignity'

Allowing the creation of babies with DNA from three biological parents in Britain is "incompatible with human dignity" and tantamount to eugenics, members of the Council of Europe have claimed.

http://www.telegraph.co.uk/science/s...n-dignity.html


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Old October 7th, 2013, 01:51 PM   #42
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Nobel Prize in Physiology or Medicine 2013 – live blog

James E Rothman, Randy W Schekman and Thomas C Südhof have won the Nobel Prize in Physiology or Medicine for their work on the mechanism that controls the transport of membrane-bound parcels or 'vesicles' through cells

http://www.theguardian.com/science/2...2013-live-blog


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Old October 19th, 2013, 02:27 PM   #43
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Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey

O Noel Gill et al, BMJ 2013;347:f5675

http://www.bmj.com/content/347/bmj.f5675

Objectives To carry out a further survey of archived appendix samples to understand better the differences between existing estimates of the prevalence of subclinical infection with prions after the bovine spongiform encephalopathy epizootic and to see whether a broader birth cohort was affected, and to understand better the implications for the management of blood and blood products and for the handling of surgical instruments.

Design Irreversibly unlinked and anonymised large scale survey of archived appendix samples.

Setting Archived appendix samples from the pathology departments of 41 UK hospitals participating in the earlier survey, and additional hospitals in regions with lower levels of participation in that survey.

Sample 32 441 archived appendix samples fixed in formalin and embedded in paraffin and tested for the presence of abnormal prion protein (PrP).

Results Of the 32 441 appendix samples 16 were positive for abnormal PrP, indicating an overall prevalence of 493 per million population (95% confidence interval 282 to 801 per million). The prevalence in those born in 1941-60 (733 per million, 269 to 1596 per million) did not differ significantly from those born between 1961 and 1985 (412 per million, 198 to 758 per million) and was similar in both sexes and across the three broad geographical areas sampled. Genetic testing of the positive specimens for the genotype at PRNP codon 129 revealed a high proportion that were valine homozygous compared with the frequency in the normal population, and in stark contrast with confirmed clinical cases of vCJD, all of which were methionine homozygous at PRNP codon 129.

Conclusions This study corroborates previous studies and suggests a high prevalence of infection with abnormal PrP, indicating vCJD carrier status in the population compared with the 177 vCJD cases to date. These findings have important implications for the management of blood and blood products and for the handling of surgical instruments.
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Old October 21st, 2013, 05:52 AM   #44
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This one is old, but nonetheless it's really important:

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Cuba creates four anti-cancer vaccines, media ignores it

That Cuba has already developed four vaccines or inoculations against different types of cancer is without doubt important news for humanity. The World Health Organisation says each year about 8 million people die from this illness.

However, the international mainstream media have almost totally ignored this news.

Last year, Cuba patented the first therapeutic vaccine against advanced lung cancer in the world, called CIMAVAX-EGF. In January, the second one, called Racotumomab, was announced.

Clinical testing in 86 countries shows that these vaccines, although they don’t cure the illness, do managed to reduce tumours and allow for a stable stage of the illness, thereby increasing hope and quality of life.

The Molecular Immunology Centre of Havana, a Cuban state organisation, is the creator of all these vaccines.
Source: https://www.greenleft.org.au/node/53426
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Old October 21st, 2013, 06:13 AM   #45
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They did it because Cuba is Communist and the media hates communism in democracy. Even if Cuba had flying cars, an active space program on Pluto, and found the answer to living forever, the dumb democratic media would condemn it and say that Cuba is terrorist and force all people to go against those great scientific discoveries. I wouldn't be surprised if a communist country found a drug that would make you live forever, but democratic states would want their citizens to die and not live till 50 just because a country is communist.
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Old October 22nd, 2013, 11:56 PM   #46
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It would cost the researchers nothing to submit these findings to Nature, Science, the Lancet or any other big peer reviewed journal. If the research is robust enough then it will be published.
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Old October 25th, 2013, 03:10 AM   #47
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IBM microfluidics tech designed to improve cancer diagnosis

A technique to pump tiny amounts of marker fluids onto a test sample could enable many more tests during a biopsy and therefore a better understanding of a person's cancer.



IBM's device for speeding up the identification of cancer cells pumps a tiny amount of fluid through a very small tip into a biopsy sample on a microscope. The tip then sucks the fluid back out again so it doesn't stain more than a tiny patch.

ZURICH -- Researchers accustomed to designing tiny features on microprocessors have taken up a new tiny-technology challenge: improving the diagnostic tests used to spot cancer.

Using a procedure called a biopsy, pathologists today closely examine cells to try to determine if a person has cancer and if so, details about what type. Such tests use chemical markers that can spotlight a variety of problems, including different types of cancer, but the tiny slice that constitutes a biopsy sample isn't big enough for a multitude of tests.

IBM's approach, which University Hospital Zurich plans to test in the coming months, uses a chip technology called microfluidics to shrink the area required for such tests to a square patch just 100 micrometers wide -- about the same as a human hair. It pumps the marker chemical down one tiny channel into the biopsy sample, then slurps it back up with a second channel to keep the marker from spreading beyond the confines of its designated patch, and a pathologist watches on a microscope to see the response.



This silicon-based "microfluidics" device channels tiny amounts of special liquids onto a biopsy specimen so pathologists can identify different forms of cancer.

"It's a very economical way of using critical tissue samples," said Emmanuel Delamarche, an IBM Research Zurich expert in nanotechnology matters such as self-assembling devices. A typical sample measuring 1 square centimeter has room for 500 test patches on just 5 percent of its surface, he said.

With the technique today, a pathologist can steer the tip around with a joystick so it puts down the marker in just the right area; the channels in the tip itself are just a few millonths of a meter wide. With several reservoirs of markers attached, the pathologist can switch among several markers.



Researcher Emmanuel Delamarche, from IBM's Zurich labs explains the company's technique for speeding up the identification of cancer cells.

In the initial incarnation, a pathologist watches the results on a display. But Delamarche hopes eventually the system could work much more automatically: A sample is inserted into a box and test results emerge shortly afterward without human intervention.



Govind Kaigala from IBM Research in Zurich demonstrates the microfluidics technology mounted atop an inverted microscope (one that looks upward). He positions the device, attached to the end of the brass-colored stalk, over a slide containing a biopsy specimen. A joystick in his right hand changes position, and with his left he points to reservoirs of the marker chemicals used to identify cancer cells.

"We need to partner to re-engineer our technology to make it into an instrument that is very reliable," Delamarche said.

SOURCE: http://news.cnet.com/8301-11386_3-57...cer-diagnosis/
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Old October 25th, 2013, 03:11 AM   #48
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On the Horizon - Next Generation MRI



Since 2006, German and French researchers have been working on developing the next generation Magnetic Resonance Imaging (MRI) technology which is now getting closer to reality. This technology will dramatically improve our ability to detect early signs of brain diseases including as Alzheimer’s and Parkinson’s as well as improve our understanding of their formation inside the brain- hopefully leading to better treatments.

The Imaging of Neuro disease Using high-field MR And Contrastophores or INUMAC is the (long) name given to an ambitious project which is the result of cooperation between members of a French-German consortium, including the University of Freiburg (Germany), Siemens Medical Solutions (Germany), Bruker BioSpin GmbH (Germany), the French Commissariat à l'énergie atomique (CEA, France), Guerbet (France) and Alstom (France).

This $270 million project aims to build a giant superconducting electromagnet capable of producing unparallel field of 11.75 teslas for use in an MRI device. For comparison, most existing hospital MRI units only produce 1.5-3 teslas and the very latest scanners currently in existence (in a handful of universities worldwide) have 9.4 teslas - which interestingly is stronger than the magnets used for the Large Hadron Collider in CERN (with "only" about 8.4 teslas). And in case you ever wondered what these teslas mean in real life - the answer is that they can lift a 60 ton tank in the air (however if you want to lift a non magnetic entity using magnets you will need much more than that - as the winners of the 2000 ig Nobel prize discovered when they used a 16 tesla superconducting electromagnet to lift a frog in mid air for 30 seconds).

As you might expect, the INUMAC magnets are huge. They will have a diameter of 4 meters (13 feet) a length of 4 meters and will weigh 150 tons. The magnets will be cooled by superfluid liquid helium to 1.8 kelvin (-271 degrees Celsius) in order to operate effectively. The device is extremely complex. creating the main superconducting coil was a giant task requiring the making of 170km (over 100 miles) of coil as well as another 60km (37 miles) or so for a secondary "protective" coil.

According to Pierre Védrine, director of the project at the French Alternative Energies and Atomic Energy Commission, typical hospital MRIs have a spatial resolution of about 1 millimeter (something that can cover the size of about 10 000 neurons in the brain) and have a temporal resolution of about 1 sec. The future INUMAC scanner will be able to image an area of about 0.1 mm (or as small as or 1000 neurons), and observe changes inside the living brain occurring at 1/10 of a second. This will be a huge leap forward for brain researchers, allowing them to learn more about how the brain functions.

Védrine believes that the fully assembled magnets will be ready in September 2014 and that the entire device will be ready for initial operation in early 2015 - ushering a new age of brain research and diagnostics.

SOURCE:http://thefutureofthings.com/news/11...ation-mri.html
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Old October 26th, 2013, 03:43 AM   #49
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New TedCas Integration Brings Touch-Free 3D Motion Control to Doctors



Dedicated to revolutionizing the access to and handling of medical information within sterile healthcare environments, TedCas provides natural user interfaces based on optoelectronic devices so that physicians may access digital information and images from patients in real time, touch-free. TedCas is a Wayra company.



TedCas has today announced its integration with the LeapMotion Controller, which allows users to interact with their computers through natural hand and figure movements in the air. The Leap Motion Controller works with computers running Mac OS X 10.7 and 10.8 as well as Windows 7 and 8.

The integrated TedCas software brings touch-free 3D motion control to doctors. It is currently under trial in six hospitals and two medical research centers around the world, including facilities in Spain, Ireland, the United States and, in Latin America, Argentina and Chile.

SOURCE: http://pulsosocial.com/en/2013/10/15...ol-to-doctors/
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Old October 28th, 2013, 07:32 PM   #50
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Alzheimer's insight from DNA study

A clearer picture of what causes Alzheimer's disease is emerging after the largest ever analysis of patients' DNA.

A massive international collaboration has now doubled the number of genes linked to the dementia to 21.

The findings, published in the journal Nature Genetics, indicate a strong role for the immune system.

Alzheimer's Research UK said the findings could "significantly enhance" understanding of the disease.

The number of people developing Alzheimer's is growing around the world as people live longer.

http://www.bbc.co.uk/news/health-24670848


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Old October 28th, 2013, 11:03 PM   #51
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Quote:
Originally Posted by Guajiro1 View Post
Cuba has already developed four vaccines or inoculations against different types of cancer is without doubt important news for humanity. The World Health Organisation says each year about 8 million people die from this illness.

However, the international mainstream media have almost totally ignored this news.

Last year, Cuba patented the first therapeutic vaccine against advanced lung cancer in the world, called CIMAVAX-EGF. In January, the second one, called Racotumomab, was announced.
Quote:
Originally Posted by Сталин View Post
They did it because Cuba is Communist and the media hates communism in democracy. Even if Cuba had flying cars, an active space program on Pluto, and found the answer to living forever, the dumb democratic media would condemn it and say that Cuba is terrorist and force all people to go against those great scientific discoveries. I wouldn't be surprised if a communist country found a drug that would make you live forever, but democratic states would want their citizens to die and not live till 50 just because a country is communist.
Nonsense. Scientists don't get their information from "the mainstream media" and mostly laugh at articles there.

Just for fun, I Googled "Racotumomab" and easily found this citation/abstract on the US National Library of Medicine's web site:

Quote:
Front Oncol. 2012 Oct 23;2:150. doi: 10.3389/fonc.2012.00150. eCollection 2012.

Racotumomab: an anti-idiotype vaccine related to N-glycolyl-containing gangliosides - preclinical and clinical data.
Vázquez AM, Hernández AM, Macías A, Montero E, Gómez DE, Alonso DF, Gabri MR, Gómez RE.
Source
Center of Molecular Immunology Havana, Cuba.
Abstract
Neu-glycolyl (NeuGc)-containing gangliosides are attractive targets for immunotherapy with anti-idiotype mAbs, because these glycolipids are not normal components of the cytoplasmic membrane in humans, but their expression has been demonstrated in several human malignant tumors. Racotumomab is an anti-idiotype mAb specific to P3 mAb, an antibody which reacts to NeuGc-containing gangliosides, sulfatides, and other antigens expressed in tumors. Preparations containing racotumomab were able to induce a strong anti-metastatic effect in tumor-bearing mice. Different Phase I clinical trials have been conducted in patients with advanced melanoma, breast cancer, and lung cancer. The results of these clinical trials demonstrated the low toxicity and the high immunogenicity of this vaccine. The induced antibodies recognized and directly killed tumor cells expressing NeuGcGM3. A Phase II/III multicenter, controlled, randomized, double blind clinical trial was conducted to evaluate the effect of aluminum hydroxide-precipitated racotumomab vaccine in overall survival in patients with advanced non-small cell lung cancer. The clinical results of this study showed a significant clinical benefit in the patients who were treated with the anti-idiotype vaccine.
http://www.ncbi.nlm.nih.gov/pubmed/23110257

Any scientist wishing to expand on this work or to utilize it in any way would have done as I did and then gone to the original publication in Frontiers of Oncology. Mainstream media would have had nothing to do with it.
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Old October 29th, 2013, 02:18 AM   #52
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Alzheimer's insight from DNA study

A clearer picture of what causes Alzheimer's disease is emerging after the largest ever analysis of patients' DNA.

A massive international collaboration has now doubled the number of genes linked to the dementia to 21.

The findings, published in the journal Nature Genetics, indicate a strong role for the immune system.

Alzheimer's Research UK said the findings could "significantly enhance" understanding of the disease.

The number of people developing Alzheimer's is growing around the world as people live longer.

http://www.bbc.co.uk/news/health-24670848


Very nice. This research might be able to help stop brain decay as we will soon be able to live forever possibly. I also have my doubts on shifting human consciousness into a computer, as that may only make a copy of a consciousness but it wont be "you". Therefore methods of preventing brain decay are very important.
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Old October 29th, 2013, 02:23 AM   #53
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Quote:
Originally Posted by Cal_Escapee View Post
Nonsense. Scientists don't get their information from "the mainstream media" and mostly laugh at articles there.

Just for fun, I Googled "Racotumomab" and easily found this citation/abstract on the US National Library of Medicine's web site:


http://www.ncbi.nlm.nih.gov/pubmed/23110257

Any scientist wishing to expand on this work or to utilize it in any way would have done as I did and then gone to the original publication in Frontiers of Oncology. Mainstream media would have had nothing to do with it.
Some countries might not be in relationships with the west, which would not allow for such medical information to pass through. Western scientists might hear about it on the news, but not have the actual experiment procedures or data because of political blocks between countries.

For example, if North Korea found the cure to cancer(or some other disorder), do you really think they would give that data to the US? It would be blocked because of political reasons.
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Old October 29th, 2013, 03:04 AM   #54
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Gelatin-Based Bio-Ink Allows Tissue And Organ Printing



German researchers have developed a new gelatin bio-ink that can be used by 3D printing technology to produce various tissue types, a breakthrough that brings the world one step closer to being able to print tissues and organs.

Scientists have long been working to improve methods and procedures for artificially producing tissue. In the current work, researchers at Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB) in Stuttgart, Germany, developed a suitable bio-ink for 3D printing that consist of gelatin-based components from natural tissue matrix and living cells. Gelatin is a well-known biological material derived from collagen that serves as the main constituent of native tissue.

The IGB researchers were able to chemically modify the gelling behavior of the gelatin to adapt the biological molecules for printing. This allowed the bio-ink to remain fluid during printing, instead of gelling like unmodified gelatin. Once the bio-inks are irradiated with UV light, they crosslink and cure to form hydrogels – polymers containing a large amount of water (just like native tissue), but which are stable in aqueous environments and when heated to 98.6 degree Fahrenheit – the average temperature of the human body.

The chemical modification of these biological molecules can be controlled so that the resulting gels have differing strengths and swelling characteristics, allowing researchers to imitate various properties of natural tissue – from solid cartilage to soft adipose tissue.

The IGB research facility also prints synthetic raw materials that can serve as substitutes for the extracellular matrix, such as systems that cure to a hydrogel devoid of by-products, which can immediately be populated with genuine cells.

“We are concentrating at the moment on the ‘natural’ variant. That way we remain very close to the original material. Even if the potential for synthetic hydrogels is big, we still need to learn a fair amount about the interactions between the artificial substances and cells or natural tissue. Our biomolecule-based variants provide the cells with a natural environment instead, and therefore can promote the self-organizing behavior of the printed cells to form a functional tissue model,” said Dr. Kirsten Borchers in describing the approach at IGB.

The printers at IGB’s labs in Stuttgart have a lot in common with conventional office printers – the ink reservoirs and jets are all the same. The differences are only observable upon close inspection, such as the heater on the ink container with which the right temperature is set for the bio-inks. The number of jets and tanks is also smaller than those in the office counterpart.

“We would like to increase the number of these in cooperation with industry and other Fraunhofer Institutes in order to simultaneously print using various inks with different cells and matrices. This way we can come closer to replicating complex structures and different types of tissue,” said Borchers.

The researchers said their current challenge is to produce vascularized tissue that has its own system of blood vessels through which the tissue can be provided with nutrients. To reach this goal, IGB is collaborating with partners under the EU-supported Project ArtiVasc 3D, which seeks to develop a technology platform to generate fine blood vessels from synthetic materials to create artificial skin with subcutaneous adipose tissue.

“This step is very important for printing tissue or entire organs in the future. Only once we are successful in producing tissue that can be nourished through a system of blood vessels can printing larger tissue structures become feasible,” said Borchers.

The development of suitable bio-inks represents an important step towards 3D printing of tissues and organs, for which demand is expected to soar in the coming years due to an aging population and advancements in the field of transplantation medicine.

SOURCE:http://www.redorbit.com/news/health/...inting-102513/
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Old November 1st, 2013, 02:09 PM   #55
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Romanian scientists create artificial blood



Romanian scientists have created a blood-like liquid that could be used in surgery or for transfusions in case of accidents. The artificial blood contains a protein from sea worms. It has been tested on mice and the team behind the work says the results are encouraging.

SOURCE: http://www.euronews.com/2013/10/31/r...ificial-blood/
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Old November 7th, 2013, 12:07 PM   #56
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Exclusive: 'Jaw-dropping' breakthrough hailed as landmark in fight against hereditary diseases as Crispr technique heralds genetic revolution

Thursday 07 November 2013

A breakthrough in genetics – described as “jaw-dropping” by one Nobel scientist – has created intense excitement among DNA experts around the world who believe the discovery will transform their ability to edit the genomes of all living organisms, including humans.

The development has been hailed as a milestone in medical science because it promises to revolutionise the study and treatment of a range of diseases, from cancer and incurable viruses to inherited genetic disorders such as sickle-cell anaemia and Down syndrome.

For the first time, scientists are able to engineer any part of the human genome with extreme precision using a revolutionary new technique called Crispr, which has been likened to editing the individual letters on any chosen page of an encyclopedia without creating spelling mistakes. The landmark development means it is now possible to make the most accurate and detailed alterations to any specific position on the DNA of the 23 pairs of human chromosomes without introducing unintended mutations or flaws, scientists said.

[...]

“Crispr is absolutely huge. It’s incredibly powerful and it has many applications, from agriculture to potential gene therapy in humans,” said Craig Mello of the University of Massachusetts Medical School, who shared the 2006 Nobel Prize for medicine for a previous genetic discovery called RNA interference.

“This is really a triumph of basic science and in many ways it’s better than RNA interference. It’s a tremendous breakthrough with huge implications for molecular genetics. It’s a real game-changer,” Professor Mello told The Independent.

Read more:

http://www.independent.co.uk/news/sc...n-8925295.html






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Old November 16th, 2013, 10:36 AM   #57
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Cancer diversity has 'huge implications'

By James Gallagher
Health and science reporter, BBC News

A single tumour can be made up of many separate cancers needing different treatments, say researchers.

A team at the Institute of Cancer Research, London, have developed a new technique for measuring the diversity within a cancer.

They showed "extraordinary" differences between cancerous cells and say new targeted drugs may fail as they may be unable to kill all the mutated tissue.

Experts said the findings would have "profound implications" for treatments.

A tumour starts as a single cell, which acquires mutations and eventually divides uncontrollably. But that is not the end of the process.

Cancerous cells continue to mutate and become more aggressive, move round the body and resist drugs.

This process is chaotic and results in a "diverse" tumour containing cancerous cells that have mutated in different ways.

"This has huge implications for medicine," researcher Prof Mel Greaves told the BBC.

http://www.bbc.co.uk/news/health-24957089


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Old November 16th, 2013, 10:48 AM   #58
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what's more disturbing is that many therapies targetting one type of cancer will induce mutations in other systems nearby or will enhance another already existing tumor. Example: one drug that inhibits prostate cancer has been shown to significantly enhance esophageal cancer.
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Old December 7th, 2013, 04:58 PM   #59
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Bacterium Reverses Autismlike Behavior in Mice

Doses of a human gut microbe helped to reverse behavioral problems in mice with autism-like symptoms, researchers report today in Cell. The treatment also reduced gastrointestinal problems in the animals that were similar to those that often accompany autism in humans.

Read more: http://www.scientificamerican.com/ar...havior-in-mice


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Old December 15th, 2013, 10:06 AM   #60
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You Won't Believe How Accurate GE's New CT Scanner Is

Even after 40 years of service, X-ray computed tomography (better known as CT scans) can be a challenge to capture. If the patient moves even a nudge, the image will come out blurry. But with GE's new Revolution CT, doctors will be able to image the entirety of your innards in the span of a single heartbeat. Literally.

The Revolution leverages a high resolution camera paired with a motion correcting system—the medical equivalent of your camera's image stabilizer—to quickly and easily capture previously-uncooperative organs like a beating human heart.

http://gizmodo.com/ges-new-fast-ct-s...-he-1482904872





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