High ISO, fast shutter speed and handheld.. Right? Anyway, there is a reason why tripods and long shutter speeds were invented. Too increase quality of night photos. This photo is quite unsharp and has lots of soft spots. I've seen better shots from you.
No, this was with a tripod, ISO 100 and manually focused. f/4 and a one second exposure. Though I used imgur to host it to get a suitable size for this thread and I think that was a mistake, that site seems to overly compress images.
Take a look at the Flickr version here, at a high res, to prove it is sharp. http://www.flickr.com/photos/mornnb/8038872690/sizes/k/
You still should've used a smaller aperture like f/8 or f/11 to get better corner sharpness. As a bonus, you'd get some more water blur
Overall it's a good shot but the buildings are falling backwards because of the perspective distortion. You can easily fix that in PP.
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