It is. There's a lot of glare from the indoor lighting to contend with, dirt on the glass and surprisingly, spiders hanging off the building:Shooting from behind the JH tower glass is tough!
I don't know if you can use a tripod at the John Hancock Center. The Willis Tower lets you do it however. I hadn't even brought mine because this was on a school trip, so I had limited room in my luggage for it. I just ended up leading against the window and steel beams to keep my hands as steady as possible.For not having a tripod with you it certainly did. When I was there I was in some sort of restaurant if I remember correctly. Back in 2009. Are you allowed to set up a tripod there?? I recently met up with a Flickr member who visits a lot of tall buildings [restaurants on top, conference rooms, etc.] and he has a great solution for not having a tripod. It's called a beanbag. It's really small and easy to use, just make sure your lens is really close to the glass of the window and all reflections should be gone. Makes a great Christmas present